Connection between Alzheimer’s disease and gut microbiota confirmed

Researchers in Switzerland and Italy have proved a correlation between an imbalance in the gut microbiota (a wide variety of bacteria, viruses, and fungi that reside in the human gut) and the development of amyloid plaques in the brain (these ‘plaques’ are the hallmarks of Alzheimer’s disease).

The study considered a cohort of 89 people between 65 and 85 years of age, where one group suffered from Alzheimer’s disease (or other neurodegenerative diseases), and the other group did not have any memory problems.

Using brain imaging, the levels of amyloid in the brain were measured, while blood tests measured for various inflammation markers and proteins that are caused by intestinal bacteria.

It was found that certain bacterial products of the microbiota are correlated with the quantity of amyloid plaques in the brain. The next step is therefore for the researchers to identify the specific bacteria, or group of bacteria involved.

This paves the way for potential protective strategies to effectively feed the ‘good’ bacteria in the gut so those at risk can be treated well before the appearance of detectable symptoms.


If you’re interested in this topic, you can find more information in our Gut Health pillar, and by signing up to stay updated on the latest news and evidence.

You can also find more details of this study by following the links below:

• Link between Alzheimer’s disease and gut microbiota is confirmed
• Short-Chain Fatty Acids and Lipopolysaccharide as Mediators Between Gut Dysbiosis and Amyloid Pathology in Alzheimer’s Disease